Role of mTOR in Pain

Role of mTOR in Pain Juliette Lanskey Introduction Pain perception protects the human body from damage, yet when the underlying mechanisms are disrupted pain can become a debilitating condition. There are almost 10 million Britains that suffer from pain on a daily basis affecting not only their personal wellbeing and quality of life but also the economy. Back pain is an example of chronic pain and back pain alone costs the NHS around  £5billion per annum and it was reported that 4.9 million days are lost per year to british businesses (http://www.britishpainsociety.org/media_faq.htm). Unfortunately, understanding the mechanisms that go awry leading to pain that is more harmful than beneficial is proving challenging. As a result, there is a deficit in treatments available to control chronic pain despite much research. There is therefore an urgent requirement to understand the mechanisms underlying pain perception in order for the development of therapeutics to reduce the sufferings of humans and the economy. This dissertation shall focus on a potential target, the mammalian target of rapamycin (mTOR), which recent research has highlighted as playing a significant role in chronic pain. Pain Pathways The processing of painful stimuli by the nervous system is termed nociception. Pain is nociception with additional psychological and emotional inputs. Noxious stimuli cause an action potential to run through a specialised set of neurons termed by Sherrington in 1906 as nociceptors; the pain neurons. Nociceptors have free nerve endings to detect noxious stimuli and can be classified into two main groups taking messages from the periphery to the central nervous system, called Aà ¯Ã‚ Ã‚ ¤ and C fibres. Aà ¯Ã‚ Ã‚ ¤ fibres are medium-diameter, mylinated neurons and this myelination and wider diameter allows rapid signal conduction. It is the Aà ¯Ã‚ Ã‚ ¤ fibres that transmit the first, sharp, localised pain of an injury whilst C fibres which are small-diameter, unmyelinated neurons transmit slow, diffuse, secondary pain 2009CELLULARANDMOLECULAR. Hence Aà ¯Ã‚ Ã‚ ¤ fibres are crucial in rapidly signalling an injury whilst the slow, burning pain from C fibres is important for protecti on during the healing period. These primary afferent nociceptors transfer messages from the periphery to the dorsal horn of the spinal chord. The dorsal horn is particularly important for processing and modulating noxious information. The dorsal horn is composed of six rexed laminae with transition zones approximately dividing different cell types. Indeed, nociceptors terminate in particular laminae. The majority of Aà ¯Ã‚ Ã‚ ¤ fibres terminate densely in lamina I, though some do also terminate in lamina V. C fibres mainly terminate in laminae I and II, although there are also a few C fibre terminations in lamina V. Thus the majority of neurons which terminate in the superficial dorsal horn specifically respond to noxious stimuli while neurons terminating deeper in the dorsal horn tend to respond to innocurous touch (large diameter, rapid conducting Aà ¯Ã‚ Ã‚ ¢ fibres transmit such innocuous information CELLULARANDMECHANMECHS2009). It is within the dorsal horn that nociceptors synapse onto central projection neurons which transmit the noxious information up to the brain. The main central pathways run up to the brain via the thalamus or brainstem and terminate in areas such as the periaqueductal grey and the parabrachial nucleus REF. There are also descending pain pathways originating in the periaqueductal grey, rostral ventral medulla and coeruleus which pass signals to the dorsal horn modulating nociception. There are also modulating circuits in the dorsal horn composing of exitatory and inhibitory interneurons contacting further neurons in the spinal cord (Fields2006thesis). Nociceptors have a pseudo-unipolar morphology allowing bidirectional signalling. This means that nociceptors are able to transmit action potentials antidromically from the the central nervous system to the nociceptor terminals (Dubin, 2010). A result of central processing is increased sensitivity of the area at and around a site of tissue damage or inflammation (PUBHUNT). A chemical soup of cytokines and growth factors is released at the site of injury and causes an increase in the sensitivity of a subset of surrounding nociceptors. This means that these nociceptors have a reduced threshold for noxious stimuli (thus will now respond to less intense stimuli than before) and also an increased response to noxious stimuli. This sensitisation of neurons at the site of injury is called primary hyperalgesia. mTOR inhibitors do not affect primary hyperalgesia and thus it is unlikely mTOR is involved, however there is another phenomenon called secondary hyperalgesia which mTOR does seem to be involved in. Secondary hyperalgesia is when a set of neurons not directly at the site of injury but in the surrounding, undamaged area undergo an increase in sensitivity due to central processing (pubhunt). Recent studies have demonstrated t hat the mTOR plays a role in creating this sensitivity. Acute pain is the pain that follows immediately after an injury to protect the body from further damage and aid the process of healing but when pain exists for more than 3 months it is defined as chronic pain (SITETHESISMerskey and Bogduk, 1994; Russo and Brose, 1998). This chronic pain does not protect the body but rather hinders the quality of life. The pathology of chronic pain often consists of decreased pain thresholds and increased response to stimsuli; the nociceptors are more sensitive. Moreover, whilst nociceptors are generally silent, firing action potentials only when stimulated (dubin2010), in chronic pain, there is an increased tendency for spontaneous activity (JULIUSANDBASBAUMTHESIS). Altogether, chronic pain leads to allodynia (pain from a normally non-noxious stimulus), hyperalgesia (heightened sensitivity to noxious stimuli) and spontaneous pain. mtor The mammalian target of rapamycin is a regulator a number of cellular processes including synaptic plasticity, protein synthesis and cellular metabolism (XONCUETALTHESIS). It is a molecule belonging to the kinase family and forms two complexes with raptor; mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). It is when part of these complexes that it administrates its cellular functions though much more is known about mTORC1 and so it is predominantly the role of mTORC1 in pain perception that this dissertation shall focus on. Signalling cascade There is a signalling cascade involving mTOR, the downstream targets of which lead to cellular activities resulting in the organisation of the cytoskeleton, the regulation of metabolism and cell survival (wullschlegerTHESIS). The signalling cascade is initiated by a signal such as a neurotransmitter acting on transmembrane receptors which activate phosphoinosital 3 kinase-AKT pathway. This results in the phosphorylation and thereby the activation of mTOR. Phosphorylated mTOR in turn phosphorylates the 4E-binding protein and in this phosphorylated state the 4E-binding protein is unable to bind and thus inhibit a protein called eIF4E. So when mTOR is activated it has the downstream affect of enabling eIF4E to associate with eIF4G, this is an essential step for initiating translation (TJ PRICE GERANTON). The fact that mTOR plays such a significant role in the regulation of translation is a hint of its importance in pain plasticity. Previously, it was thought by some that translation could only occur in the cell soma. However, others noted both the half-life of axonal proteins and the time it takes for a protein to travel down the length of the axon and concluded that the axoplasmic transport is too slow for protein synthesis only to occur in the cell soma HUNT. Indeed, following the discovery of ribosomes and ‘Golgi outposts’ in dendritic spines it is now believed that local protein synthesis at the sites of dendritic synapses plays a significant role in plasticity (2009REVIEW). Research demonstrates that chronic pain arises as a result of plastic changes that occur during persistent acute pain. During any pain there are noxious signals to the central nervous system enabling the pain to be perceived, if these signals persist it has been shown that this causes and maintains plastic changes that result in chronic pain. Indeed, it has been shown through advanced structural imaging methods that there are large scale alterations in the brain structure of sufferers of chronic pain CHRONICPAINPLASTICITY. There is relatively little research into the possibilities of targeting this pain plasticity to help patients cope with chronic pain in comparison with genetic studies. It is consequentially an exciting new avenue of exploration and the role of mTOR in pain plasticity is of particular interest. EARLIER As mTOR plays such a crucial role in cellular function it is unsurprising that mTOR dysfunction is believe to be involved in a number of maladies. The role of mTOR in cancer, diabetes and neurodegeneration is being explored and a number of mTOR inhibitors have already been tested for treating certain maladies. For example†¦..This has demonstrated that mTOR inhibitors are potential treatment regimes BUT THERE ARE SIDEEFFECTS MTOR THESIS MTOR SIGNALLING MTOR PLASTICITY see 2009reviewnociception and AMPKPG 6 is v good Dealing with pain MTOR AND RESEARCH thesis 2 Pain Pathways and Plasticity 3 The mammalian target of rapamycin 2007 Decreased Nociceptive Sensitization in Mice Lacking the Fragile X Mental Retardation Protein: Role of mGluR1/5 and mTOR – mTOR’s role in nociceptive synaptic plasticity through translation regulation; ‘ the mTOR inhibitor rapamycin inhibited formalin- and DHPG-induced nociception’ †¦. mTOR is a major regulator of protein synthesis for it controls the initiation of translation (PUBLISHEDHUNT2009). It is thought that by controlling protein translation it maintains the sensitivity of nociceptors following local injury. Targetting mTOR could reduce the secondary hyperalgesia that occurs from pain and thus help patients cope with pain†¦ 4 The mTOR signalling cascade Unicellular organisms that are sensitive to nutrient availability in their environment control translation via a rapamycin-sensitive translation pathway. This process is controlled by a protein kinase, TOR, which is blocked by rapamycin. Interestingly, neurons appear to have co-opted this evolutionarily conserved mechanism to control activity-dependent local translation. Mammalian TOR, or mTOR, is activated by neurotransmitter receptor signaling cascades and phosphorylates downstream factors that control translation. Hence, mTOR is intricately involved in synaptic plasticity in the CNS, a mechanism that is linked to its role in controlling translation in dendrites (Jaworskiet al., 2006). The major mechanism of mTOR-regulated translation is control of the initiation of cap-dependent translation (depicted in Fig 1) (Gingras et al., 2004). This occurs because one of the major targets of mTOR phosphorylation is the elongation associated factor 4E-BP (Gingraset al., 1999). 4E-BP binds c c ap-binding factor eIF4E and, when it is hypo-phosphorylated, inhibits the formation of the eIF4E/eIF4G elongation complex preventing translation. When 4E-BP is hyper-phosphorylated, 4E-BP dissociates from eIF4E allowing eIF4G binding and the initiation of cap-dependent translation. Recently a small molecule inhibitor of eIF4G binding to eIF4E was discovered (4EGI-1) and this molecule inhibits cap-dependent translation (Moerke et al., 2007). Hence, mTOR is crucial for regulating activity-dependent translation in neurons via its regulation of elongation factors (Bankoet al., 2006; Tanget al., 2002; Tsokaset al., 2007) and the mTOR pathway is amenable to specific pharmacological manipulation. 6 Experiments suggesting inhibiting mTOR could help control pain 2007 Decreased Nociceptive Sensitization in Mice Lacking the Fragile X Mental Retardation Protein: Role of mGluR1/5 and mTOR – mTOR’s role in nociceptive synaptic plasticity through translation regulation; ‘ the mTOR inhibitor rapamycin inhibited formalin- and DHPG-induced nociception’ NOT THAT RELEVANT – basically saying that because of mutation translation can’t happen properly†¦meaning mTOR has less control. However there is a subsection with rapamycin injections which does show decreased nociception with rapamycin 2011 – systemic inhibition of mTOR – mTOR regulation of nociceptive sensitivity; ‘ inhibiting the mTORC1 pathway systemically alleviated mechanical hypersensitivity in mouse models’ Good intro relating mTOR to chronic pain Local cutaneous intrathecal administration of rapamycin blocks activation of downstream targets of mTORC1 alleviating mechanical hypersensitivity – 21, 29 3 43 46 62 SHOULD PUT 1 OR 2 LOCAL EXPERIMENTS BEFORE THIS ONE If targeting mTORC1 signaling pathway has a potential thera- peutic application for controlling chronic pain, systemic rather than local administration (as has been used previously [21,29]) requires further investigation. Here we examined the effective- ness of temsirolimus (CCI-779), a clinically used rapamycin ester derivative, given systemically

Greek Inspired Architecture in Boston, MA

Greek Architecture in Boston My first discovery of classical architecture was made the moment I stepped outside my apartment, as my building has two Doric columns framing the front door. As I meandered over the hill and across the Common I realized exactly how prevalent classical architecture really is. Elements of classical architecture can be found on almost every building in the old residential neighborhoods and many commercial buildings feature columns and arches as well.I saw all three orders of columns, arches, and even a dome. The only architectural element I was unable to find was a iron vault. The Massachusetts State House, about half a block from my apartment, has many examples of classical architecture including a large gold dome, twelve Corinthian columns, and seven arches visible from outside. The State House, which houses the state legislature and the governor's offices, was built in 1798 by leading architect of the time Charles Bullfinch.The dome was originally made ou t of wood shingles but has since been sheathed in copper and covered in 23 karat gold. (http:// www. Satisfaction. Gob/formalities/mischievousness's. Asp) As far as I observed he arches and columns follow the rules of the classical orders except that the frieze above the columns is blank. I'm not sure if the frieze above Corinthian columns is traditionally blank or not. A pioneer, which signifies the importance of the logging industry in Massachusetts, tops the dome. Http://www. Satisfaction. Gob/formalities/ mischievousness's. Asp) I doubt this would be found on domes of the ancient world. Just as classical architecture was meant to convey power and grace in Ancient Greece and Rome, I'm sure Charles Bullfinch used elements are classical architecture n the design of the State House for the purpose of conveying the wealth, power, and beauty of the government and state of Massachusetts. Another building that incorporates classical elements is the Boston Museum of Fine Art.The current MFC building was built in 1909. There are rows of ionic columns and construction that looks like post-and-lintel. In the area that would be the frieze it says â€Å"Museum of Fine Arts† which could probably be loosely considered a continuous frieze. It was especially interesting to me to see the post-and-lintel type openings since most alluding seem to prefer the Roman's arches over the Ancient Greek post-and-lintel system. The Museum of Fine Art is another building that, due to its purpose, should convey an air of greatness.The last building I would like to use as an example is my apartment building, which was built in 1909. There are likely hundreds of residential apartment buildings in the area whose doors are flanked by a column on each side, particularly the apartments that were built in the early sass. The columns of my apartment building are of the Doric order but the abacus of each is rounded, not angular. (Strickland peg 15) There is a session but no cornice, pedimen t, or any other aspect of the Doric order. At night the columns are illuminated.It is clear by the emphasis the building management places on the columned entrance that they believe it to denote a sense of wealth, greatness, or class. While the State House and MFC certainly do this, I find my building does not quite succeed. It feels that without any other of the classical elements the columns are lacking. It is particularly interesting to me how long classical architecture has been in style. It as been used for centuries on everything from prominent government buildings to much more humble residences.Architecture that was once reserved for temples and important public spaces can now be found on everything from strip malls to pharmacies. An important difference in the use of the classical architectural elements is that Ancient Greeks built in their style partly for the logical purpose of creating a building that will stand. Today, even more so than in Ancient Rome, many aspects of t he architecture are purely ornamental. Http:// consistory. Schenectady. Org/temple-of-portions. HTML

The Basics of Samples of Autobiography Essay for College

The Basics of Samples of Autobiography Essay for College What You Need to Do About Samples of Autobiography Essay for College Before You Miss Your Chance Choosing our service, you will understand that studying can be simple if you gain from the help of capable experts. The primary goal of essay writing services is to assist you with issue and support at the same time you write your paper. After discovering our website, you will no longer will need to bother friends and family with these kinds of requests. Another benefit of our website is the quickness. The Upside to Samples of Autobiography Essay for College Additionally, an excellent autobiography sample can provide you some ideas of what things to write about or enable you to remember certain events from your life. All events are put in chronological order. Although autobiographies are usually summations of pivotal events in your life, the events you opt for may differ based on the class curriculum. Capitalize on the tr aits and events which make you different from the remainder of your classmates. Introducing Samples of Autobiography Essay for College Writing an essay isn't only collecting the different info. You can trust the very best essay help online. Your college essay should contain information that are related to the instruction provided to you. In this instance, attempt to hit the minimal words required and make sure that the essay you will write is packed with relevant info and useful particulars. A seasoned professional will make an error-free assignment right away and can help you boost your grades. Even when you're not at the surface of your class, writing about what motivates and drives you'll show admissions officers that you're prepared to work hard to achieve what you desire. If you're going to include details that could directly hit the requirements of the school, then it is easy to get the approvalA that you should be accepted for enrollment. Students lead busy lives an d frequently forget about an approaching deadline. Underline the major idea of your writing and what's going to be disclosed. An autobiography is a significant means to tell men and women in precisely the same situation that there's a way out. There's no correct or wrong time for selecting the title for life story. Check yet another time if it's simple to follow and produces a vivid picture in the reader's mind. Make the reader want to read the entire essay in 1 breath. Possessing good essay examples provides the reader an in-depth and on-the-court idea about what a well structured and coherent essay appears like. In this way, it's going to be simpler to structure the content of your essay. Before you even begin writing the content of your college essay, there are a few essay writing basic guide that you need to always bear in mind. The duration of your essay is not what universities search for. Autobiography essays are usually between 1000 to 3000 words but it totally is based on the writer. Before you commence writing your college essay, you may choose to see the essay examplesA that we've listed for you, so you may have more idea on what things to put in the college essay which you will create. Writing a college admission essay can be quite tough. Board members are going to have place to create announcements and bring up community difficulties. Apart from the principal requirements you must follow if you'd like to compose an exemplary essay, there are some additional details that are crucial. Once you own a topic, it's best to make an outline of ideas. Make an outline and adhere to a coherent method to describe it. The Samples of Autobiography Essay for College Game Just because you've already written a college essay for a single university doesn't mean that it may also apply on your next applicatio ns. Make sure whatever event you decide on relates straight to the angle your professor has assigned. What subjects you enjoy, if you want to connect your college studies to them, or why you will pick a different career path, and so forth. When you're assigned to supply the specifics of your life to a professor in college, or even your peers in the class, you might feel hesitant to include things like the main pieces of your history you don't feel very pleased with. This autobiography example is ideal for both college and higher school students. Developing an excellent college essay are able to lose its purpose in the event the content of what you've written is not what the university is asking for. Writing the college application essay can be among the most daunting elements of applying to college. Also, there aren't any word limits for an autobiography, but in some instances it is going to be highly recommended to make it as brief as possible. It has often being found that autobiography essay is a little expository in nature and in some specific cases might be based on prejudice. Thus, when you plan your autobiography, make certain to concentrate on events that had significant effect on your life and totally ignore the tidbits. If you're suffering from low self-esteem, when you believe your life is meaningless, or you merely feel sad write an autobiography. You may as well start right with the story rather than putting a very long autobiography introduction. How to begin writing an autobiography is dependent upon what sort of it you are writing. If you don't understand how to compose an autobiography in the suitable way it's time to learn from the very best writing examples. Even if you're writing an official autobiography for work, you still must entice the reader with good text. Many are highly-reputed. There's no place more important to create a decent first impression than on paper. 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Life after Death, Reincarnation, Resurrection and...

Life after Death, Reincarnation, Resurrection and Immortality of the Soul Belief in life after death has taken many forms, some which are unique in particular religious belief systems, though; others can be found in more than one religion. For most religions, life after death is an article of faith. In Western religions, the belief is founded in scriptural evidence, but for all religions the belief in life after death is the same: life after death has been promised to humans by an all powerful[1] There are many views of life after death in particular which have been much adhered to and much discussed by philosophers. This essay will attempt to put forward some of the key ideas and arguments†¦show more content†¦And if human beings can exist without their bodies then the view that they can survive death seems a plausible one. We normally think of death as the end of a persons bodily life. But if people are distinct from their bodies, then the fact that their body dies does not entail that they die. This view that the body can survive as a disembodied state does not lack modern supporters. According to Richard Swimburne it is coherent to suppose that a person can exist without a body. Swimburne argues that if X can be without Y then X and Y are distinct. This view that a people are essentially other that their bodies is referred to dualism. There are a number of points, which seem to go in favour of this view on life after death. For one there is the fact that we often naturally talk as if our real selves were distinct from our bodies- as for instance, when we say we have bodies and as when we agree that we can be the same person over a number of years even though our bodily make- up has dramatically changed in the meantime. Other views for life after death, which fit into the motion of dualism, include the immortality of the soul and the reincarnation of a person. 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William Wordsworth, a nineteenth-century author, was no exception to this universal dilemma of considering death as the absolute end of one ¡Ã‚ ¯s existence or the beginning of one ¡Ã‚ ¯s existence in a new setting.  ¡Ã‚ °Nothing was more difficultRead MoreIn This 21St Century People Continue To Wonder What Their1965 Words   |  8 Pagesto wonder what their destiny will be after death; pe rhaps people have many definitions and explanation about it. Hence, people are struggling to reconcile to one common understanding. These questions I believe remain our questions today. Now, having this understanding in mind I believe there is a great need for a clear and coherent explanation of Eschatology. Every human being long for some consolation in the face of death. The most destressing aspects of death is that is separates. It seems thisRead MoreCompare and contrast two beliefs about life after death. 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No person truly knows what happens after a person ceases to live in the world, except for the people themselves who have passed away. As a result, over the course of history, people of various backgrounds, ethnicities, and religions have speculated and believed in numerous different possibilities for the destinyRead MoreThe Is The Unlimited Extension Of A Person s Existence2878 Words   |  12 PagesIntroduction and thesis Immortality is the unlimited extension of a person’s existence, even after the event of death.(3) The afterlife is the extension of one’s life in another realm, but not specifically eternally. Immortality on the other hand suggests everlasting existence, even if the body isn t still alive. Immortality is an unrestricted characteristic of spirituality. Human beings have been referred to as mortals, where immortals have been classified as gods. The notion that life can exist forever

Racism in the Bluest Eye - 752 Words

Racism in â€Å"The Bluest Eye† Several examples of racism are encompassed in The Bluest Eye by Toni Morrison. Characters who are members of the black community are forced to accept their status as the â€Å"others†, or â€Å"outsiders†, which has been imposed on them by the white community. In turn, blacks assign this status to other individuals within the lighter-skinned black community. In this novel, characters begin to internalize the racism presented by these people, and feel inferior. The stereotype torments them mentally, and in some cases, to the point of insanity. The character most affected by racism is Pecola Breedlove. Pecola Breedlove’s character is defined by several different types of racism. It is present in her family, especially†¦show more content†¦Racism becomes one of the most critical themes in the novel and causes the most destruction. In The Bluest Eye, the reader can see how Toni Morrison demonstrates the effects of racism on the black community. In Pecola’s case, she is driven to the edge of insanity, where she longs to be a white person with beautiful blue eyes, and who lives in a world where racism does not exist. She longs for that world where nobody will hurt her anymore because she is not one of the â€Å"others†. White people did not have to deal with the same dilemmas as black people did, and could never understand the consequences of beingShow MoreRelatedRacism In The Bluest Eye Essay1730 Words   |  7 Pages Racism In The Bluest Eyes The Bluest Eye tells a tragic story of a young girl named Pecola who desperately wishes for beautiful blue eyes. Pecola believes that the only way she will ever be beautiful is if she has blue eyes. This story takes place in the 1970’s, a time where African Americans were second class citizens in society. They were often exploited and dehumanized because of the way they looked, and this will leave a long lasting effect. 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When Maureen goes out for ice cream with Pecola, Frieda, and Claudia, the girls talk about menstruationRead MoreRacism in Toni Morrisons The Bluest Eye Essay1955 Words   |  8 Pages Since childhood, we all have been taught that â€Å"racism is bad† and should be avoided at all costs. We have been told that â€Å"everyone is a child of God and we are all created equal.† In fact, Americans are praised for the so-called equality they possess. However, renowned author Toni Morrison sheds light on the sheltered and unspoken truth that everyone—to some extent—is racist. â€Å"Home† is a reflective essay in which Morrison explains that her triumphs against racist ideologies are evident throughoutRead MoreEssay about Racism and Sexism in the Bluest Eye1798 Words   |  8 PagesToni Morrison, the author of The Bluest Eye, centers her novel around two things: beauty and wealth in their relation to race and a brutal rape of a young girl by her father. Morrison explores and exposes these themes in relation to the underlying factors of black society: racism and sexism. Every character has a problem to deal with and it involves racism and/ or sexism. Whether the characters are the victim or the aggressor, they can do nothing about their problem or condition, especially when concerningRead MoreRacism And Sexism In Toni Morrisons The Bluest Eye2105 Words   |  9 PagesHow does racism and sexism play a part in the novel, The Bluest Eye? Have you ever experienced or seen racism and/or sexism and you were not able to help make the situation better? Throughout the novel The Bluest Eye, the author, Toni Morrison takes us on a journey of an eleven-year-old girl named Pecola Breedlove whose love for blond hair and blue eyes affects how she perceives everyone around her. The novel takes place in Lorain, Ohio where Morrison grew up. Pecola wishes for blue eyes because sheRead MoreBluest Eye1268 Words   |  6 Pagesa black African could write a good book† (Satwase). In the Bluest Eye Toni Morrison uses wrong and discomfort to show the crushing consequences that come from racism. In 1950 America, racial discrimination was implied by different skin colors. The Bluest Eye shows ways in which white beauty standards hurt lives of black females, blacks that discriminate on each other and the community’s bias on who you were. Toni Morrison uses the racism of the 1950 s and shows that It is the blackness that accounts Read MoreAnalysis Of Tony Morrison s The Bluest Eye 1263 Words   |  6 Pages Pecola’s Eyes and Vision Tony Morrison is a famous, exciting, American writer, describes as a major figure of the entire African American nation within the American community. â€Å"The Bluest Eye† published in 1970, is one of the most impressive novels of the author describing the Great American Depression. The contexts and the structure of the story looks as if it was written for children. This realistic story describes the manner of life and reality of the African American, suffering form the pressureRead MoreAnalysis Of Tony Morrison s The Bluest Eye 1314 Words   |  6 PagesvvPecola’s Eyes and Vision Tony Morrison is a famous, exciting, American writer, describes as a major figure of the entire African American nation within the American community. â€Å"The Bluest Eye† published in 1970, is one of the most impressive novels of the author describing the Great American Depression. The contexts and the structure of the story looks as if it was written for children. This realistic story describes the manner of life and reality of the African American, suffering form the pressure

The Psychological Effect of Abortion on Women Free Essays

{draw:g} Natasha Joseph Ms. Powell College Writing 2 Thesis: The psychological effect of abortion on women? What is Abortion? The termination of an early pregnancy. Is it a health risk? Why do many have abortions? Pro-Life vs. We will write a custom essay sample on The Psychological Effect of Abortion on Women? or any similar topic only for you Order Now Pro-Choice When life does begin? Should abortion be illegal? How does abortion affect your health? Signs of complications after abortion Physically and Mentally The Psychological effect of Abortion on women. Conclusion What is Abortion? One of the most controversial issues in the United States is abortion. Abortion is the termination of pregnancy after twelve weeks of gestation (Wikipedia. com). Some miscarriage and stillbirths can be defined as accidental abortion. There are many different methods in having an abortion. Some induced abortions are performed using one of several methods. The safest and most useful and appropriate method is determined by the age of the fetus, or the length of pregnancy, which is calculated from the beginning of the pregnant woman’s last menstrual period. Most pregnancies last an average of 39 to 40 weeks, about 9 months. So abortions are performed in the first trimester of the pregnancy because it is easier and safer because the fetus is much smaller. When terminating a pregnancy they are often health risk such as breast cancer, Cervical or ovarian cancers and could cause labor complication later in life if you decide to have a child. The more abortion you have the more it increases the change of health problems. So before you have an abortion you should look at other choices like adoption. The majority of abortions are mostly due to the fact of teenage pregnancy. There are many reason people have abortions. Some of the reasons are they are unable to take care of a child financially, not ready to raise a child, have a abusive relationship with their partner and they don’t want to bring a child into the kind of atmosphere, have been a victim of rape and finally having a child would have serious health complication. Pro-life vs. Pro-choice Abortion has been a conflict between the pro-life and pro-choice movement. The question is when does life begins? Life begins at the conception when the egg is fertilized by the sperm. The pro-life moments considers undeveloped human life is sacred and must be protected by the government. They want abortion to illegal everywhere regardless of the circumstances. When groups of the pro-life and pro-choice debate on abortion they overlook the fact the many women who have abortion have no choice in the matter. There are many who have abortions just to do so but most have no other options available to them but to terminate a life that they may not want to. A lot of people are debating whether or not abortion should be illegal but who have the right to tell you what to do with your body. Many believe that abortion is murder no matter when a person believes life becomes official. There are many reasons abortion should be illegal including the descriptive and disturbing stories about how aborted babies sometime scream as they come out and the looks of pain on their faces. The health threat to the mother after going through with the procedure as well as the lifelong health risks that remain should be good enough reasons abortion should be illegal. With the rising healthcare costs and instance of disease greater than the medical ability to solve the problems, continued health remains important to all people. Self induced problems such as voluntary termination of pregnancy leads to complications for future pregnancies, reproductive disease, and depression. There many couples available for adopting these children by way of impotence by one or both people this is another option beside having an abortion How abortion does affect your life? Abortion is a life changing event for most women not just a medical procedure which can cause physical, spiritual and emotional consequences. When you get an abortion some risk are involved as with any operation. Some of the risk include heavy bleeding with is cause when the cervix is being torn or punctured after the operation. Any risk is an infection that is caused when some of the fetus is left inside of the womb and cause you to have a pelvic infection. Sometimes you can have an incomplete abortion where unwanted fetal parts left inside the uterus and this can lead to a hysterectomy which is the removal of the uterus. After abortion at least 50% of women are affected by breast cancer. Many women suffer with emotional and psychological problems after experiencing abortion. Some of these problems are depression; acute feeling of grief and fear of disclosure, eating disorders, suicide tendencies, anxiety and also increased consumption of alcohol and drugs. These are some of the risks involved in abortion. So think before you go for an abortion surgery. Avoid abortion, unless and until it is obligatory in terms of your health and you were a victim of abused. The psychological effect of abortion on women Most women feel some relief immediately after the abortion procedure, though there is often sadness as well. Natural hormonal changes related to pregnancy can cause a woman to feel more emotional than usual. Post-abortive women may experience a variety of feelings, including sadness, anger, regret, guilt, or even numbness. Women who have experienced abortion often report symptoms typical of depressive and anxiety disorders, such as sleeplessness, tearfulness, anxiety, hopelessness, irritability, and an inability to concentrate. These problems can be confounded by relationship difficulties that are often both a cause and effect of the abortion decision. The disorder of having negative effects after an abortion is called Post Abortion Syndrome or PAS. (Allied Action Inc. 996, 1). Although many women experience these problems for only a short period, many others have emotional difficulties for a long period after the abortion. These may manifest as clinical depression, an anxiety disorder, substance abuse, an eating disorder, or sexual difficulties. Women who already have problems such as these before an abortion may have a worsening of symptoms as a result of the abortion. Such difficultie s can last for months or even years. (Allied Action Inc. 1996, 1). Conclusion Many women have an abortion for different reasons. The majority of abortions that occurs within the United States are that of Teenagers and single young adults. Abortion is one of the most controversy topics today in Society and Politics. Abortion is a women right to choose what is best for her. Although at time I think there should be some restrictions on Abortions; whereas abortions should only be given to women in serious cases such as if your health is at risk or you have been a victim of rape or any form of abuse. You should think seriously before you have an abortion because it is a life altering decision. Works Cited Hutchison. â€Å"A Feminist Approach to Post-Abortion Counseling†. Herizons, June 1997: 23-24 Reardon, David c. Abortion Risks and Complications, (1997), 2000 Elliot Institute. Retrieved July 28, 2009. http://www. afterabortion. org/physica. html Stacey, Dawn, Abortion Procedures, (July 09, 2009) Retrieved July 28, 2009. http://contraception. about. com/od/contraceptionfailure/a/aboutabortion_2. htm Allied Action Inc. Post Abortion Syndrone, 1996 The National Office of Post-Abortion Reconciliation and Healing Impact of Abortion on the Family; IRLF Newsletter, 1993 How to cite The Psychological Effect of Abortion on Women?, Papers

Debut Albums and Great Friend free essay sample

The person Im close to the most is my friend. Her name is Thong. We have known each other since I was in grade 7. To me, she is really special girl. Not only does she has a good appearance, she also has a good personality. She is cute and pretty. She has long black hair, a round face and a straight nose. Especially, she has a charming smile with two dimples, which made a strong impression on me at the first time I met her. However, the thing that makes everybody like her the most is her personality. She is very modest.Shes one of the best pupil in my class. Shes good at every subject, but she never showed pride in her abilities and always tried to learn harder. Besides, shes always ready to help her friends in their study. Thats why many people in my class cherished her. We will write a custom essay sample on Debut Albums and Great Friend or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Furthermore, she is very warm-hearted, friendly and sociable. She likes to make friend with everybody and takes part in the society organizes. As a matter of fact, she became a student of the medical university now. Moreover, to me, she is a great friend who always knows how to take care and share.Whenever Im sad or cheerful, happy or In sorrow, shes always next to me to share with me. Sometimes, I get into trouble, which makes me tired ,worried and discouraged, she is always willing to come beside me, help me calm down, give me helpful advice so that I can come over. Not only that, she Is very reliable, I can share her my secrets without a bit worries. She Is really a person who always listens to me, understands me every time and every where. Thats why she became my close friend. I always feel proud because of having a great friend likes her on my side.